2016a). This lesser increase was proportionate towards the lesser peak of PEA degrees detected in human volunteers as opposed with beagle dogs. This distinction, consequently, could be due to the lessen complete amount of PEA acutely administered to human volunteers (about ∼5 vs. thirty mg·kg−one in canine) and also to the fact that this was
c. decreased MC degranulation within the ear pinna in reaction to area administration of compound P by 35% as compared to nine% for saline. Apparently, a shorter chain NAE, NThe exogenous administration of PEA may in this kind of scenarios serve to replenish amounts of endogenous PEA, restoring its protective, anti-inflammatory and analgesic effect
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